PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9857269-4 1998 Recently, a novel cytochrome P450 enzyme (CYP26) with specific RA 4-hydroxylase activity, which is rapidly induced by RA, has been cloned from man, mouse and zebra fish, fullfilling all requirements of an enzyme which could be of crucial importance in controlling steady-state levels of active retinoids in cells and target tissues, thus protecting against excessive exposure. Tretinoin 63-65 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 42-47 9857269-4 1998 Recently, a novel cytochrome P450 enzyme (CYP26) with specific RA 4-hydroxylase activity, which is rapidly induced by RA, has been cloned from man, mouse and zebra fish, fullfilling all requirements of an enzyme which could be of crucial importance in controlling steady-state levels of active retinoids in cells and target tissues, thus protecting against excessive exposure. Retinoids 294-303 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 42-47 9857269-5 1998 Besides the putative role of this newly identified CYP26 in contributing to susceptibility of cancer cells to retinoids, the possible function of this gene in early embryonic development is discussed. Retinoids 110-119 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 51-56