PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9727025-0	1998	AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene.	Cyclic AMP	25-29	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3	
9727025-0	1998	AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene.	Cyclic AMP	25-29	dopamine beta-hydroxylase	Rattus norvegicus	46-71	
9727025-2	1998	For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regulation of gene expression by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis.	Catecholamines	8-21	dopamine beta-hydroxylase	Rattus norvegicus	44-69	
9727025-2	1998	For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regulation of gene expression by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis.	Cyclic AMP	129-139	dopamine beta-hydroxylase	Rattus norvegicus	44-69	
9727025-2	1998	For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regulation of gene expression by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis.	Diglycerides	141-156	dopamine beta-hydroxylase	Rattus norvegicus	44-69	
9727025-6	1998	Transfection of a dominant negative JunD expression plasmid inhibits cAMP-mediated expression of the dopamine beta-hydroxylase promoter construct in PC12 and CATH.a cells.	Cyclic AMP	69-73	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-40	
9727025-6	1998	Transfection of a dominant negative JunD expression plasmid inhibits cAMP-mediated expression of the dopamine beta-hydroxylase promoter construct in PC12 and CATH.a cells.	Cyclic AMP	69-73	dopamine beta-hydroxylase	Rattus norvegicus	101-126	
9727025-7	1998	In addition to the role of c-Fos in regulating dopamine beta-hydroxylase gene expression in response to cAMP, a second pathway, involving Rap1/B-Raf is involved.	Cyclic AMP	104-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32	
9727025-7	1998	In addition to the role of c-Fos in regulating dopamine beta-hydroxylase gene expression in response to cAMP, a second pathway, involving Rap1/B-Raf is involved.	Cyclic AMP	104-108	dopamine beta-hydroxylase	Rattus norvegicus	47-72	
9727025-8	1998	These experiments illustrate an unusual divergence of cAMP-dependent protein kinase signaling through multiple pathways that then reconverge on a single element in the dopamine beta-hydroxylase promoter to elicit activation of gene expression.	Cyclic AMP	54-58	dopamine beta-hydroxylase	Rattus norvegicus	168-193