PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9673359-0 1998 Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line. Phytic Acid 75-78 tumor protein p53 Homo sapiens 43-46 9673359-3 1998 We hypothesize that the tumor suppressor genes such as p53 and WAF1/CIP1 may be involved in mediating the anti-neoplastic action of IP6 p53 acts as a molecular policeman prevention of genetically damaged cells; it causes the cells to arrest in the G1 phase of cell cycle, and regulates the level of p21waf1/cip1 which acts as a growth inhibitor. Phytic Acid 132-135 tumor protein p53 Homo sapiens 55-58 9673359-3 1998 We hypothesize that the tumor suppressor genes such as p53 and WAF1/CIP1 may be involved in mediating the anti-neoplastic action of IP6 p53 acts as a molecular policeman prevention of genetically damaged cells; it causes the cells to arrest in the G1 phase of cell cycle, and regulates the level of p21waf1/cip1 which acts as a growth inhibitor. Phytic Acid 132-135 tumor protein p53 Homo sapiens 136-139 9673359-4 1998 We therefore investigated the effects of IP6 on the expression of p53 and WAF1/p21 in HT-29 human colon carcinoma by immunocytochemistry and quantitative ELISA. Phytic Acid 41-44 tumor protein p53 Homo sapiens 66-69 9673359-5 1998 Our immunocytochemical studies with anti p53 antibodies (wild type-PAb246 and PAb1620) and anti p21waf1/cip1 (EA10) antibodies demonstrated an increased level of p53 and p21waf1/cip1 after 3 and 6 days of treatment with 3.3 and 5 mM IP6. Phytic Acid 233-236 tumor protein p53 Homo sapiens 162-165 9673359-6 1998 Quantitative assay for p53 and p21waf1/cip1 by ELISA did not show detectable levels in untreated control cells, while strong expression of p53 and p21waf1/cip1 protein by 3.3 and 5 mM IP6 was seen on day 3 and day 6 of treatment. Phytic Acid 184-187 tumor protein p53 Homo sapiens 139-142 9673359-8 1998 These data demonstrate that IP6 up-regulates the expression of the tumor suppressor gene p53 and p21WAF1/CIP1 gene and their modulation may be one of the mechanisms of the anti-neoplastic action of IP6. Phytic Acid 28-31 tumor protein p53 Homo sapiens 89-92 9673359-8 1998 These data demonstrate that IP6 up-regulates the expression of the tumor suppressor gene p53 and p21WAF1/CIP1 gene and their modulation may be one of the mechanisms of the anti-neoplastic action of IP6. Phytic Acid 198-201 tumor protein p53 Homo sapiens 89-92 9673359-9 1998 Since loss of p53 function enhances cancer cells" resistance to chemotherapeutic agents, the stimulating function of IP6 on p53 makes it an attractive adjuvant chemotherapeutic agent as well. Phytic Acid 117-120 tumor protein p53 Homo sapiens 124-127