PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9673359-0	1998	Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line.	Phytic Acid	75-78	tumor protein p53	Homo sapiens	43-46	
9673359-3	1998	We hypothesize that the tumor suppressor genes such as p53 and WAF1/CIP1 may be involved in mediating the anti-neoplastic action of IP6 p53 acts as a molecular policeman prevention of genetically damaged cells; it causes the cells to arrest in the G1 phase of cell cycle, and regulates the level of p21waf1/cip1 which acts as a growth inhibitor.	Phytic Acid	132-135	tumor protein p53	Homo sapiens	55-58	
9673359-3	1998	We hypothesize that the tumor suppressor genes such as p53 and WAF1/CIP1 may be involved in mediating the anti-neoplastic action of IP6 p53 acts as a molecular policeman prevention of genetically damaged cells; it causes the cells to arrest in the G1 phase of cell cycle, and regulates the level of p21waf1/cip1 which acts as a growth inhibitor.	Phytic Acid	132-135	tumor protein p53	Homo sapiens	136-139	
9673359-4	1998	We therefore investigated the effects of IP6 on the expression of p53 and WAF1/p21 in HT-29 human colon carcinoma by immunocytochemistry and quantitative ELISA.	Phytic Acid	41-44	tumor protein p53	Homo sapiens	66-69	
9673359-5	1998	Our immunocytochemical studies with anti p53 antibodies (wild type-PAb246 and PAb1620) and anti p21waf1/cip1 (EA10) antibodies demonstrated an increased level of p53 and p21waf1/cip1 after 3 and 6 days of treatment with 3.3 and 5 mM IP6.	Phytic Acid	233-236	tumor protein p53	Homo sapiens	162-165	
9673359-6	1998	Quantitative assay for p53 and p21waf1/cip1 by ELISA did not show detectable levels in untreated control cells, while strong expression of p53 and p21waf1/cip1 protein by 3.3 and 5 mM IP6 was seen on day 3 and day 6 of treatment.	Phytic Acid	184-187	tumor protein p53	Homo sapiens	139-142	
9673359-8	1998	These data demonstrate that IP6 up-regulates the expression of the tumor suppressor gene p53 and p21WAF1/CIP1 gene and their modulation may be one of the mechanisms of the anti-neoplastic action of IP6.	Phytic Acid	28-31	tumor protein p53	Homo sapiens	89-92	
9673359-8	1998	These data demonstrate that IP6 up-regulates the expression of the tumor suppressor gene p53 and p21WAF1/CIP1 gene and their modulation may be one of the mechanisms of the anti-neoplastic action of IP6.	Phytic Acid	198-201	tumor protein p53	Homo sapiens	89-92	
9673359-9	1998	Since loss of p53 function enhances cancer cells" resistance to chemotherapeutic agents, the stimulating function of IP6 on p53 makes it an attractive adjuvant chemotherapeutic agent as well.	Phytic Acid	117-120	tumor protein p53	Homo sapiens	124-127