PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9612301-2 1998 Using the whole cell patch-clamp technique in rat intrapulmonary arterial smooth muscle cells, we found that ET-1 and the voltage-dependent K+ (Kv)-channel antagonist 4-aminopyridine, but not the Ca(2+)-activated K(+)-channel antagonist charybdotoxin (ChTX), caused membrane depolarization. Charybdotoxin 237-250 endothelin 1 Rattus norvegicus 109-113 9612301-2 1998 Using the whole cell patch-clamp technique in rat intrapulmonary arterial smooth muscle cells, we found that ET-1 and the voltage-dependent K+ (Kv)-channel antagonist 4-aminopyridine, but not the Ca(2+)-activated K(+)-channel antagonist charybdotoxin (ChTX), caused membrane depolarization. Charybdotoxin 252-256 endothelin 1 Rattus norvegicus 109-113 9612301-3 1998 In the presence of 100 nM ChTX, ET-1 (10(-10) to 10(-7) M) caused a concentration-dependent inhibition of K+ current (56.2 +/- 3.8% at 10(-7) M) and increased the rate of current inactivation. Charybdotoxin 26-30 endothelin 1 Rattus norvegicus 32-36