PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9495846-1 1998 The present report describes in vitro studies demonstrating that the heterocyclic substituted pyridine compound (+/-)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429) is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 +/- 17 nM; Emax = 110 +/- 09% vs. nicotine). pyridine 94-102 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 218-239 9495846-1 1998 The present report describes in vitro studies demonstrating that the heterocyclic substituted pyridine compound (+/-)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429) is extremely potent in activating human muscle nicotine ACh receptor (nAChR) (EC50 = 59 +/- 17 nM; Emax = 110 +/- 09% vs. nicotine). pyridine 94-102 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 241-246