PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9477973-1 1998 Two tyrosyl residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family: autophosphorylation of Tyr416 (c-Src numbering) located in the catalytic domain correlates with enzyme activation, while Csk-mediated phosphorylation of the C-terminal tyrosine Tyr527 (c-Src numbering) gives rise to inactive forms of Src kinases. Tyrosine 92-100 C-terminal Src kinase Homo sapiens 249-252