PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9402154-9	1997	These results suggest that upregulation of ICAM-1, VCAM-1, and E selectin expression is associated with oxidative stress induced by hemoglobin/heme and that HO-1 may play a modulating role via its ability to degrade heme to a substance with antioxidant properties.	Heme	216-220	selectin E	Homo sapiens	63-73	
9402154-0	1997	Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells.	Heme	0-4	intercellular adhesion molecule 1	Homo sapiens	50-56	
9402154-0	1997	Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells.	Heme	0-4	vascular cell adhesion molecule 1	Homo sapiens	58-64	
9402154-0	1997	Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells.	Heme	0-4	selectin E	Homo sapiens	70-80	
9402154-2	1997	To investigate the mechanism of heme-induced endothelial cell activation, we analyzed the effect of heme and the inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), on the expression of the heme-degrading stress protein, heme oxygenase (HO), and adhesion molecules in human umbilical vein endothelial cells (HUVEC).	Heme	32-36	tumor necrosis factor	Homo sapiens	165-174	
9402154-3	1997	Indirect immunofluorescence double labeling studies demonstrated a simultaneous increase of ICAM-1 and HO-1 after exposure of cells to heme for 24 hr.	Heme	135-139	intercellular adhesion molecule 1	Homo sapiens	92-98	
9402154-3	1997	Indirect immunofluorescence double labeling studies demonstrated a simultaneous increase of ICAM-1 and HO-1 after exposure of cells to heme for 24 hr.	Heme	135-139	heme oxygenase 1	Homo sapiens	103-107	
9402154-5	1997	Dot blot immunoassay and quantitative analysis by ELISA demonstrated that heme treatment for 24 hr caused a 2-fold increase in ICAM-1 expression (P < 0.002) compared with quiescent cells, while in cells stimulated by TNF-alpha for 24 hr ICAM-1 gene expression increased by 5-fold.	Heme	74-78	intercellular adhesion molecule 1	Homo sapiens	127-133	
9402154-5	1997	Dot blot immunoassay and quantitative analysis by ELISA demonstrated that heme treatment for 24 hr caused a 2-fold increase in ICAM-1 expression (P < 0.002) compared with quiescent cells, while in cells stimulated by TNF-alpha for 24 hr ICAM-1 gene expression increased by 5-fold.	Heme	74-78	tumor necrosis factor	Homo sapiens	220-229	
9402154-5	1997	Dot blot immunoassay and quantitative analysis by ELISA demonstrated that heme treatment for 24 hr caused a 2-fold increase in ICAM-1 expression (P < 0.002) compared with quiescent cells, while in cells stimulated by TNF-alpha for 24 hr ICAM-1 gene expression increased by 5-fold.	Heme	74-78	intercellular adhesion molecule 1	Homo sapiens	240-246	
9402154-6	1997	Moreover, heme exposure also resulted in a marked increase in VCAM-1 and E selectin expression (three and four times over control levels, respectively).	Heme	10-14	vascular cell adhesion molecule 1	Homo sapiens	62-68	
9402154-6	1997	Moreover, heme exposure also resulted in a marked increase in VCAM-1 and E selectin expression (three and four times over control levels, respectively).	Heme	10-14	selectin E	Homo sapiens	73-83	
9402154-8	1997	The level of HO activity in endothelial cells exposed to heme or TNF-alpha was increased from 24.7 +/- 5.7 pmol bilirubin/mg protein/min in control to 70.0 +/- 9.5 and 36.7 +/- 3.1 pmol bilirubin/mg protein/min in heme- and TNF-alpha-stimulated cells, respectively.	Heme	57-61	tumor necrosis factor	Homo sapiens	224-233	
9402154-8	1997	The level of HO activity in endothelial cells exposed to heme or TNF-alpha was increased from 24.7 +/- 5.7 pmol bilirubin/mg protein/min in control to 70.0 +/- 9.5 and 36.7 +/- 3.1 pmol bilirubin/mg protein/min in heme- and TNF-alpha-stimulated cells, respectively.	Bilirubin	112-121	tumor necrosis factor	Homo sapiens	65-74	
9402154-8	1997	The level of HO activity in endothelial cells exposed to heme or TNF-alpha was increased from 24.7 +/- 5.7 pmol bilirubin/mg protein/min in control to 70.0 +/- 9.5 and 36.7 +/- 3.1 pmol bilirubin/mg protein/min in heme- and TNF-alpha-stimulated cells, respectively.	Bilirubin	186-195	tumor necrosis factor	Homo sapiens	65-74	
9402154-8	1997	The level of HO activity in endothelial cells exposed to heme or TNF-alpha was increased from 24.7 +/- 5.7 pmol bilirubin/mg protein/min in control to 70.0 +/- 9.5 and 36.7 +/- 3.1 pmol bilirubin/mg protein/min in heme- and TNF-alpha-stimulated cells, respectively.	Heme	214-218	tumor necrosis factor	Homo sapiens	65-74	
9402154-9	1997	These results suggest that upregulation of ICAM-1, VCAM-1, and E selectin expression is associated with oxidative stress induced by hemoglobin/heme and that HO-1 may play a modulating role via its ability to degrade heme to a substance with antioxidant properties.	Heme	143-147	intercellular adhesion molecule 1	Homo sapiens	43-49	
9402154-9	1997	These results suggest that upregulation of ICAM-1, VCAM-1, and E selectin expression is associated with oxidative stress induced by hemoglobin/heme and that HO-1 may play a modulating role via its ability to degrade heme to a substance with antioxidant properties.	Heme	143-147	vascular cell adhesion molecule 1	Homo sapiens	51-57	
9402154-9	1997	These results suggest that upregulation of ICAM-1, VCAM-1, and E selectin expression is associated with oxidative stress induced by hemoglobin/heme and that HO-1 may play a modulating role via its ability to degrade heme to a substance with antioxidant properties.	Heme	143-147	selectin E	Homo sapiens	63-73	
9402154-9	1997	These results suggest that upregulation of ICAM-1, VCAM-1, and E selectin expression is associated with oxidative stress induced by hemoglobin/heme and that HO-1 may play a modulating role via its ability to degrade heme to a substance with antioxidant properties.	Heme	216-220	intercellular adhesion molecule 1	Homo sapiens	43-49	
9402154-9	1997	These results suggest that upregulation of ICAM-1, VCAM-1, and E selectin expression is associated with oxidative stress induced by hemoglobin/heme and that HO-1 may play a modulating role via its ability to degrade heme to a substance with antioxidant properties.	Heme	216-220	heme oxygenase 1	Homo sapiens	157-161