PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9264313-3 1997 Differences in pharmacokinetic parameters of alfentanil have previously been associated with the wide distribution of CYP3A4, the only known hepatic cytochrome P450 monooxygenase (CYP) involved in the conversion of alfentanil to noralfentanil. Alfentanil 45-55 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 118-124 9264313-3 1997 Differences in pharmacokinetic parameters of alfentanil have previously been associated with the wide distribution of CYP3A4, the only known hepatic cytochrome P450 monooxygenase (CYP) involved in the conversion of alfentanil to noralfentanil. Alfentanil 215-225 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 118-124 9264313-5 1997 Microsomes prepared from different human liver samples were compared for their abilities to metabolize fentanyl, sufentanil and alfentanil, and it was found that disappearance of the three substrates was well correlated with immunoreactive CYP3A4 contents but not with other CYPs, including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6 and CYP2E1. Alfentanil 128-138 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 240-246