PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9200468-0 1997 NKR-P1A stimulation of arachidonate-generating enzymes in rat NK cells is associated with granule release and cytotoxic activity. Arachidonic Acid 23-35 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 0-7 9200468-2 1997 The aim of the present work was to assess whether NKR-P1A receptor triggering also induced arachidonic acid (AA) generation and to determine the possible role of this event on granule release and cytotoxicity. Arachidonic Acid 91-107 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 50-57 9200468-3 1997 We demonstrated that activation of fresh peripheral blood rat NK cells by cross-linking with the anti-NKR-P1A 3.2.3 mAb induced calcium-dependent AA release, which is due to the activation of cytosolic phospholipase A2 (cPLA2), secretory phospholipase A2 (sPLA2), and diacylglycerol/monoacylglycerol lipase. Calcium 128-135 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 102-109 9200468-3 1997 We demonstrated that activation of fresh peripheral blood rat NK cells by cross-linking with the anti-NKR-P1A 3.2.3 mAb induced calcium-dependent AA release, which is due to the activation of cytosolic phospholipase A2 (cPLA2), secretory phospholipase A2 (sPLA2), and diacylglycerol/monoacylglycerol lipase. Calcium 128-135 phospholipase A2 group IVA Rattus norvegicus 192-218 9200468-3 1997 We demonstrated that activation of fresh peripheral blood rat NK cells by cross-linking with the anti-NKR-P1A 3.2.3 mAb induced calcium-dependent AA release, which is due to the activation of cytosolic phospholipase A2 (cPLA2), secretory phospholipase A2 (sPLA2), and diacylglycerol/monoacylglycerol lipase. Calcium 128-135 phospholipase A2 group IVA Rattus norvegicus 220-225 9200468-3 1997 We demonstrated that activation of fresh peripheral blood rat NK cells by cross-linking with the anti-NKR-P1A 3.2.3 mAb induced calcium-dependent AA release, which is due to the activation of cytosolic phospholipase A2 (cPLA2), secretory phospholipase A2 (sPLA2), and diacylglycerol/monoacylglycerol lipase. Calcium 128-135 phospholipase A2 group IIA Rattus norvegicus 228-254 9200468-3 1997 We demonstrated that activation of fresh peripheral blood rat NK cells by cross-linking with the anti-NKR-P1A 3.2.3 mAb induced calcium-dependent AA release, which is due to the activation of cytosolic phospholipase A2 (cPLA2), secretory phospholipase A2 (sPLA2), and diacylglycerol/monoacylglycerol lipase. Calcium 128-135 phospholipase A2 group IIA Rattus norvegicus 256-261 9200468-3 1997 We demonstrated that activation of fresh peripheral blood rat NK cells by cross-linking with the anti-NKR-P1A 3.2.3 mAb induced calcium-dependent AA release, which is due to the activation of cytosolic phospholipase A2 (cPLA2), secretory phospholipase A2 (sPLA2), and diacylglycerol/monoacylglycerol lipase. Calcium 128-135 monoglyceride lipase Rattus norvegicus 283-306 9200468-4 1997 We also documented the presence of a type II sPLA2 activity in the supernatant fluids from NKR-P1A-activated rat NK cells, suggesting that AA and lysophospholipids could be mobilized from the outside of the cell. Lysophospholipids 146-163 phospholipase A2 group IIA Rattus norvegicus 45-50 9200468-4 1997 We also documented the presence of a type II sPLA2 activity in the supernatant fluids from NKR-P1A-activated rat NK cells, suggesting that AA and lysophospholipids could be mobilized from the outside of the cell. Lysophospholipids 146-163 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 91-98 9200468-6 1997 Treatment of effector cells with arachidonyl trifluoromethylketone, a cPLA2 inhibitor; p-bromophenacylbromide, a sPLA2 inhibitor; or RHC80267, a diacylglycerol lipase inhibitor, led to a partial inhibition of the redirected lysis against P815 target cells as well the granule content release induced by NKR-P1A cross-linking. arachidonyltrifluoromethane 33-66 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 70-75 9200468-6 1997 Treatment of effector cells with arachidonyl trifluoromethylketone, a cPLA2 inhibitor; p-bromophenacylbromide, a sPLA2 inhibitor; or RHC80267, a diacylglycerol lipase inhibitor, led to a partial inhibition of the redirected lysis against P815 target cells as well the granule content release induced by NKR-P1A cross-linking. arachidonyltrifluoromethane 33-66 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 113-118 9200468-6 1997 Treatment of effector cells with arachidonyl trifluoromethylketone, a cPLA2 inhibitor; p-bromophenacylbromide, a sPLA2 inhibitor; or RHC80267, a diacylglycerol lipase inhibitor, led to a partial inhibition of the redirected lysis against P815 target cells as well the granule content release induced by NKR-P1A cross-linking. arachidonyltrifluoromethane 33-66 killer cell lectin-like receptor subfamily B member 1A Mus musculus 303-310