PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9179619-0 1997 Tissue plasminogen activator (tPA) inhibits human neutrophil superoxide anion production in vitro. Superoxides 61-77 chromosome 20 open reading frame 181 Homo sapiens 0-28 9179619-0 1997 Tissue plasminogen activator (tPA) inhibits human neutrophil superoxide anion production in vitro. Superoxides 61-77 chromosome 20 open reading frame 181 Homo sapiens 30-33 9179619-1 1997 Because neutrophils contribute to reperfusion injury associated with acute myocardial infarction (MI), and because tissue plasminogen activator (tPA) is often used in the management of MI, we evaluated the effect of tPA on superoxide (O2.-) production by human neutrophils in vitro. Superoxides 223-233 chromosome 20 open reading frame 181 Homo sapiens 216-219 9179619-2 1997 We found that adding increasing amounts of tPA significantly (r = 0.89, P < 0.025) and progressively reduced O2.- generation by neutrophils treated with phorbol myristate acetate (PMA) in vitro. Superoxides 112-114 chromosome 20 open reading frame 181 Homo sapiens 43-46