PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9083277-0 1997 Prostaglandin E2 stimulates expression of matrix metalloproteinase 2 in cultured rat mesangial cells. Dinoprostone 0-16 matrix metallopeptidase 2 Rattus norvegicus 42-68 9083277-6 1997 PGE2 increased MMP-2 mRNA levels beginning at one hour of incubation and remained elevated up to 24 hours. Dinoprostone 0-4 matrix metallopeptidase 2 Rattus norvegicus 15-20 9083277-7 1997 Nuclear run off experiments revealed that the PGE2-induced increase in mRNA expression for MMP-2 is due to stimulated gene transcription. Dinoprostone 46-50 matrix metallopeptidase 2 Rattus norvegicus 91-96 9083277-8 1997 Western blot analysis and zymography revealed that MMP-2 protein production and enzyme activity was also enhanced by PGE2. Dinoprostone 117-121 matrix metallopeptidase 2 Rattus norvegicus 51-56 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. Cyclic AMP 4-8 matrix metallopeptidase 2 Rattus norvegicus 41-46 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. Cyclic AMP 4-8 matrix metallopeptidase 2 Rattus norvegicus 138-143 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. 8-Bromo Cyclic Adenosine Monophosphate 18-30 matrix metallopeptidase 2 Rattus norvegicus 41-46 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. 8-Bromo Cyclic Adenosine Monophosphate 18-30 matrix metallopeptidase 2 Rattus norvegicus 138-143 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. Dinoprostone 76-80 matrix metallopeptidase 2 Rattus norvegicus 41-46 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. Dinoprostone 76-80 matrix metallopeptidase 2 Rattus norvegicus 138-143 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. Cyclic AMP 26-30 matrix metallopeptidase 2 Rattus norvegicus 41-46 9083277-9 1997 The cAMP analogue 8-bromo-cAMP increased MMP-2 mRNA levels, suggesting that PGE2-induced generation of intracellular cAMP plays a role in MMP-2 induction in MC. Cyclic AMP 26-30 matrix metallopeptidase 2 Rattus norvegicus 138-143 9083277-10 1997 These studies demonstrate that PGE2 stimulates the transcription, protein formation and enzyme activity of MMP-2 in cultured rat MC. Dinoprostone 31-35 matrix metallopeptidase 2 Rattus norvegicus 107-112