PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8955182-0 1996 IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Wortmannin 43-53 interleukin 2 Homo sapiens 0-4 8955182-0 1996 IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Wortmannin 43-53 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 13-18 8955182-0 1996 IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 interleukin 2 Homo sapiens 0-4 8955182-0 1996 IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 13-18 8955182-0 1996 IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Sirolimus 74-83 interleukin 2 Homo sapiens 0-4 8955182-0 1996 IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Sirolimus 74-83 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 13-18 8955182-5 1996 The IL-2 adhesion response is blocked by wortmannin and LY294002, inhibitors of phosphatidylinositol-3 (PI-3) kinase activity. Wortmannin 41-51 interleukin 2 Homo sapiens 4-8 8955182-5 1996 The IL-2 adhesion response is blocked by wortmannin and LY294002, inhibitors of phosphatidylinositol-3 (PI-3) kinase activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 56-64 interleukin 2 Homo sapiens 4-8 8955182-6 1996 In contrast, rapamycin strongly inhibits IL-2-induced proliferation without inhibiting IL-2-induced adhesion. Sirolimus 13-22 interleukin 2 Homo sapiens 41-45 8955182-8 1996 IL-2R ligation rapidly (<5 min) induces tyrosine phosphorylation of several proteins, the most prominent being signal transducer and activator of transcription (Stat) proteins, the p85 subunit of the PI-3 kinase, and an as yet unidentified 125-kDa protein (p125). Tyrosine 43-51 interleukin 2 receptor subunit alpha Homo sapiens 0-5 8955182-8 1996 IL-2R ligation rapidly (<5 min) induces tyrosine phosphorylation of several proteins, the most prominent being signal transducer and activator of transcription (Stat) proteins, the p85 subunit of the PI-3 kinase, and an as yet unidentified 125-kDa protein (p125). Tyrosine 43-51 SEC23 interacting protein Homo sapiens 260-264 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. Wortmannin 0-10 SEC23 interacting protein Homo sapiens 112-116 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. Wortmannin 0-10 signal transducer and activator of transcription 3 Homo sapiens 182-187 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. Wortmannin 0-10 signal transducer and activator of transcription 5A Homo sapiens 189-194 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12-20 SEC23 interacting protein Homo sapiens 112-116 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12-20 signal transducer and activator of transcription 3 Homo sapiens 182-187 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12-20 signal transducer and activator of transcription 5A Homo sapiens 189-194 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. cytochalasin E 26-40 SEC23 interacting protein Homo sapiens 112-116 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. cytochalasin E 26-40 signal transducer and activator of transcription 3 Homo sapiens 182-187 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. cytochalasin E 26-40 signal transducer and activator of transcription 5A Homo sapiens 189-194 8955182-9 1996 Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected. Tyrosine 84-92 SEC23 interacting protein Homo sapiens 112-116 8955182-11 1996 Taken together, these data suggest that 1) IL-2R ligation induces homotypic adhesion through a wortmannin/LY294002-sensitive, rapamycin-resistant pathway, 2) tyrosine kinases play a critical role in cytokine-induced adhesion, and 3) adhesion, but not mitogenesis, correlates with enhanced tyrosine phosphorylation of an as yet unidentified protein of 125 kDa. Wortmannin 95-105 interleukin 2 receptor subunit alpha Homo sapiens 43-48 8955182-11 1996 Taken together, these data suggest that 1) IL-2R ligation induces homotypic adhesion through a wortmannin/LY294002-sensitive, rapamycin-resistant pathway, 2) tyrosine kinases play a critical role in cytokine-induced adhesion, and 3) adhesion, but not mitogenesis, correlates with enhanced tyrosine phosphorylation of an as yet unidentified protein of 125 kDa. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 interleukin 2 receptor subunit alpha Homo sapiens 43-48 8955182-11 1996 Taken together, these data suggest that 1) IL-2R ligation induces homotypic adhesion through a wortmannin/LY294002-sensitive, rapamycin-resistant pathway, 2) tyrosine kinases play a critical role in cytokine-induced adhesion, and 3) adhesion, but not mitogenesis, correlates with enhanced tyrosine phosphorylation of an as yet unidentified protein of 125 kDa. Tyrosine 158-166 interleukin 2 receptor subunit alpha Homo sapiens 43-48