PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8742240-4 1996 There are now a number of substrates reported that have routes of metabolism ascribed specifically to cytochrome P4502C9 (CYP2C9), the isoform mainly responsible for tolbutamide hydroxylation. Tolbutamide 166-177 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 102-120 8742240-4 1996 There are now a number of substrates reported that have routes of metabolism ascribed specifically to cytochrome P4502C9 (CYP2C9), the isoform mainly responsible for tolbutamide hydroxylation. Tolbutamide 166-177 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 122-128 8742240-6 1996 The substrate specificity has been rationalized in terms of a hydrogen bond donor/acceptor model and, by use of molecular modeling, an active site template model for CYP2C9 has been generated. Hydrogen 62-70 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 166-172