PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8689938-9 1995 The metabolism of tacrolimus by human small intestine was inhibited by anti-CYP3A, troleandomycin, and erythromycin, indicating that, as in the liver, CYP3A enzymes are the major enzymes for tacrolimus metabolism in the human small intestine. Tacrolimus 18-28 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 76-81 8689938-9 1995 The metabolism of tacrolimus by human small intestine was inhibited by anti-CYP3A, troleandomycin, and erythromycin, indicating that, as in the liver, CYP3A enzymes are the major enzymes for tacrolimus metabolism in the human small intestine. Tacrolimus 18-28 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 151-156 8689938-9 1995 The metabolism of tacrolimus by human small intestine was inhibited by anti-CYP3A, troleandomycin, and erythromycin, indicating that, as in the liver, CYP3A enzymes are the major enzymes for tacrolimus metabolism in the human small intestine. Tacrolimus 191-201 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 76-81 8689938-9 1995 The metabolism of tacrolimus by human small intestine was inhibited by anti-CYP3A, troleandomycin, and erythromycin, indicating that, as in the liver, CYP3A enzymes are the major enzymes for tacrolimus metabolism in the human small intestine. Tacrolimus 191-201 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 151-156 8689938-13 1995 It is concluded that tacrolimus is metabolized by cytochrome CYP3A enzymes in the small intestine. Tacrolimus 21-31 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 61-66 8689938-14 1995 The rate of the CYP3A enzymatic activities varies about 5 times from patient to patient, and drugs that interfere with the in vitro metabolism of tacrolimus in the liver also inhibit its small intestinal metabolism. Tacrolimus 146-156 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 16-21