PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8679227-8	1996	Since the identification of HO-1 in 1968, many of the studies involving this enzyme were understandably focused on the regulation and function of HO-1 in heme metabolism.	Heme	154-158	heme oxygenase 1	Homo sapiens	28-32	
8679227-8	1996	Since the identification of HO-1 in 1968, many of the studies involving this enzyme were understandably focused on the regulation and function of HO-1 in heme metabolism.	Heme	154-158	heme oxygenase 1	Homo sapiens	146-150	
8679227-9	1996	This emphasis is self-evident as HO-1 catalyzes the first and rate-limiting step in heme degradation.	Heme	84-88	heme oxygenase 1	Homo sapiens	33-37	
8679227-10	1996	Interestingly, however, evidence accumulated over the past 25 years demonstrates that HO-1 is induced not only by the substrate heme but also by a variety of non-heme inducers such as heavy metals, endotoxin, heat shock, inflammatory cytokines, and prostaglandins.	Heme	128-132	heme oxygenase 1	Homo sapiens	86-90	
8679227-10	1996	Interestingly, however, evidence accumulated over the past 25 years demonstrates that HO-1 is induced not only by the substrate heme but also by a variety of non-heme inducers such as heavy metals, endotoxin, heat shock, inflammatory cytokines, and prostaglandins.	Heme	162-166	heme oxygenase 1	Homo sapiens	86-90	
8679227-10	1996	Interestingly, however, evidence accumulated over the past 25 years demonstrates that HO-1 is induced not only by the substrate heme but also by a variety of non-heme inducers such as heavy metals, endotoxin, heat shock, inflammatory cytokines, and prostaglandins.	Prostaglandins	249-263	heme oxygenase 1	Homo sapiens	86-90	
8679227-11	1996	The chemical diversity of HO-1 inducers led to the speculation that HO-1, besides its role in heme degradation, may also play a vital function in maintaining cellular homeostasis.	Heme	94-98	heme oxygenase 1	Homo sapiens	26-30	
8679227-11	1996	The chemical diversity of HO-1 inducers led to the speculation that HO-1, besides its role in heme degradation, may also play a vital function in maintaining cellular homeostasis.	Heme	94-98	heme oxygenase 1	Homo sapiens	68-72	
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Carbon Monoxide	195-210	heme oxygenase 1	Homo sapiens	17-21	
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Carbon Monoxide	195-210	heme oxygenase 1	Homo sapiens	239-243	
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Iron	212-216	heme oxygenase 1	Homo sapiens	17-21	
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Iron	212-216	heme oxygenase 1	Homo sapiens	239-243	
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Bilirubin	222-231	heme oxygenase 1	Homo sapiens	17-21	
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Bilirubin	222-231	heme oxygenase 1	Homo sapiens	239-243