PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8278410-1 1994 The potential involvement of ceramide-related signaling processes in the induction of apoptosis by tumor necrosis factor alpha was assessed by multiple biochemical strategies in the human leukemic cell lines HL-60 and U937 and the murine fibrosarcoma cell lines L929/LM and WEHI 164/13. Ceramides 29-37 tumor necrosis factor Homo sapiens 99-126 8278410-2 1994 Exposure of these cells to tumor necrosis factor alpha resulted in internucleosomal cleavage of genomic DNA, yielding laddered patterns of oligonucleosomal fragments characteristic of apoptosis when resolved by agarose gel electrophoresis; similar responses were observed after exposure to exogenous sphingomyelinase or synthetic ceramides. Ceramides 330-339 tumor necrosis factor Homo sapiens 27-54