PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8226909-4 1993 Rab5N133I, a point mutant that has impaired ability to bind GTP or GDP, undergoes modification to a limited extent and at a severely reduced rate when compared to cognate Rab5. Guanosine Diphosphate 67-70 RAB5A, member RAS oncogene family Homo sapiens 0-4 8226909-6 1993 Since the latter mutation results in defective GTPase activity, these combined observations indicate that guanine nucleotide binding plays an important role in the geranylgeranylation reaction and suggest that the GDP-bound form of Rab5 is the preferred conformation for interaction with Rab prenyltransferase. Guanosine Diphosphate 214-217 RAB5A, member RAS oncogene family Homo sapiens 232-236