PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8220902-0 1993 Bradykinin-induced release of PGI2 from aortic endothelial cell lines: responses mediated selectively by Ca2+ ions or a staurosporine-sensitive kinase. Epoprostenol 30-34 kininogen 1 Bos taurus 0-10 8220902-2 1993 Bradykinin (100 nM) triggers release of nitric oxide and prostacyclin from both AG07680A and AG04762 bovine cultured aortic endothelial cells. Epoprostenol 57-69 kininogen 1 Bos taurus 0-10 8220902-9 1993 Exposure of AG04762 cells for 10 min to staurosporine produced a concentration-dependent inhibition (IC50 = 107 +/- 14 nM) in bradykinin-stimulated prostacyclin release. Epoprostenol 148-160 kininogen 1 Bos taurus 126-136 8220902-16 1993 In contrast, the bradykinin-dependent release of prostacyclin may involve one of two pathways (involving an increase in intracellular calcium or activation of a staurosporine-sensitive kinase), and the two pathways are selectively exploited in AG07680A and AG04762 cells, respectively. Epoprostenol 49-61 kininogen 1 Bos taurus 17-27