PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7980444-0	1994	SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism.	Guanosine Triphosphate	63-66	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-0	1994	SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism.	Guanosine Triphosphate	63-66	Rac family small GTPase 1	Homo sapiens	58-62	
7980444-0	1994	SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism.	Guanosine Diphosphate	102-105	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-2	1994	These functions are controlled by the GTP-bound form of Rac.	Guanosine Triphosphate	38-41	Rac family small GTPase 1	Homo sapiens	56-59	
7980444-3	1994	The biochemical interaction between Rac and its only known GDP-dissociation stimulator (termed smgGDS) was characterized.	Guanosine Diphosphate	59-62	Rac family small GTPase 1	Homo sapiens	36-39	
7980444-3	1994	The biochemical interaction between Rac and its only known GDP-dissociation stimulator (termed smgGDS) was characterized.	Guanosine Diphosphate	59-62	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	95-101	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	guanosine 5"-[gamma-thio]-triphosphate gtp	50-92	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	guanosine 5"-[gamma-thio]-triphosphate gtp	50-92	ras homolog family member A	Homo sapiens	111-115	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	guanosine 5"-[gamma-thio]-triphosphate gtp	50-92	Rac family small GTPase 2	Homo sapiens	117-121	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	guanosine 5"-[gamma-thio]-triphosphate gtp	50-92	Rac family small GTPase 1	Homo sapiens	123-127	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	guanosine 5"-[gamma-thio]-triphosphate gtp	50-92	RAP1A, member of RAS oncogene family	Homo sapiens	129-134	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	guanosine 5"-[gamma-thio]-triphosphate gtp	50-92	Rac family small GTPase 2	Homo sapiens	215-219	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	Guanosine Triphosphate	89-92	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	Guanosine Triphosphate	89-92	ras homolog family member A	Homo sapiens	111-115	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	Guanosine Triphosphate	89-92	Rac family small GTPase 2	Homo sapiens	117-121	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	Guanosine Triphosphate	89-92	Rac family small GTPase 1	Homo sapiens	123-127	
7980444-4	1994	SmgGDS was able to stimulate the incorporation of guanosine 5"-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2.	Guanosine Triphosphate	89-92	RAP1A, member of RAS oncogene family	Homo sapiens	129-134	
7980444-6	1994	Interestingly, the activity of smgGDS toward Rac1 could not be observed in a [3H]GDP/GTP exchange assay under conditions where it stimulated incorporation of GTP[gamma S] into Rac1.	Guanosine Triphosphate	158-161	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	31-37	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	74-76	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	19-25	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	74-76	Rac family small GTPase 1	Homo sapiens	48-52	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	74-76	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	74-76	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Diphosphate	77-80	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	19-25	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Diphosphate	77-80	Rac family small GTPase 1	Homo sapiens	48-52	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	81-84	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	19-25	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	81-84	Rac family small GTPase 1	Homo sapiens	48-52	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	167-170	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	19-25	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	167-170	Rac family small GTPase 1	Homo sapiens	48-52	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	167-170	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	167-170	Rac family small GTPase 1	Homo sapiens	162-166	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	167-170	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Triphosphate	167-170	Rac family small GTPase 1	Homo sapiens	162-166	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	330-332	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	19-25	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	330-332	Rac family small GTPase 1	Homo sapiens	48-52	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	330-332	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Tritium	330-332	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Diphosphate	333-336	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	19-25	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Diphosphate	333-336	Rac family small GTPase 1	Homo sapiens	48-52	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Diphosphate	333-336	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-7	1994	We determined that smgGDS prevented the loss of Rac1 activity during the [3H]GDP/GTP exchange assay by demonstrating the ability of smgGDS to inhibit the loss of Rac1 GTP[gamma S]-binding during incubations at 30 degrees C. This stabilizing effect was exactly counterbalanced by the ability of smgGDS to stimulate the release of [3H]GDP from Rac1, thereby producing no net observable effect in the exchange assay.	Guanosine Diphosphate	333-336	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	132-138	
7980444-8	1994	SmgGDS was able to effectively stimulate the release of GDP but not GTP[gamma S] from Rac1.	Guanosine Diphosphate	56-59	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-8	1994	SmgGDS was able to effectively stimulate the release of GDP but not GTP[gamma S] from Rac1.	Guanosine Triphosphate	68-71	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-9	1994	SmgGDS maintains Rac1 in a nucleotide-free form after release of GDP, indicating that the reaction between Rac1 and smgGDS involves a substituted enzyme mechanism.	Guanosine Diphosphate	65-68	Rap1 GTPase-GDP dissociation stimulator 1	Homo sapiens	0-6	
7980444-9	1994	SmgGDS maintains Rac1 in a nucleotide-free form after release of GDP, indicating that the reaction between Rac1 and smgGDS involves a substituted enzyme mechanism.	Guanosine Diphosphate	65-68	Rac family small GTPase 1	Homo sapiens	107-111