PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7747447-0 1995 Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acid. Okadaic Acid 120-132 nuclear factor kappa B subunit 1 Homo sapiens 37-47 7747447-1 1995 In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR. Okadaic Acid 146-158 nuclear factor kappa B subunit 1 Homo sapiens 245-255 7747447-1 1995 In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR. Okadaic Acid 160-163 nuclear factor kappa B subunit 1 Homo sapiens 245-255 7747447-3 1995 In both transformed and normal lymphocytes, OKA stimulation induced intense phosphorylation of the constitutively expressed Sp1 protein in the nucleus, a property of OKA not shared by TNF, phorbol ester, or PHA and interleukin 2. Okadaic Acid 44-47 lamin B receptor Homo sapiens 207-210 7747447-3 1995 In both transformed and normal lymphocytes, OKA stimulation induced intense phosphorylation of the constitutively expressed Sp1 protein in the nucleus, a property of OKA not shared by TNF, phorbol ester, or PHA and interleukin 2. Okadaic Acid 44-47 interleukin 2 Homo sapiens 215-228 7747447-5 1995 Our results suggest that SP1 phosphorylation induced by OKA, a selective inhibitor of the serine-threonine phosphatase PP2A, facilitates the formation of a transcription complex involving general transcription factors, HIV Tat, and Sp1 proteins. Okadaic Acid 56-59 protein phosphatase 2 phosphatase activator Homo sapiens 119-123