PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7702566-3 1995 Therefore, activation of Gs (by cholera-toxin pre-treatment) amplified the bradykinin-stimulated cyclic AMP signal and concurrently attenuated the partial activation of extracellular-signal-regulated kinase-2 (ERK-2) by bradykinin. Cyclic AMP 97-107 kininogen 1 Homo sapiens 75-85 7702566-4 1995 We have previously demonstrated that, in order to induce full activation of ERK-2 with bradykinin, it is necessary to obliterate PKC-stimulated cyclic AMP formation. Cyclic AMP 144-154 kininogen 1 Homo sapiens 87-97 7702566-8 1995 The present study indicates that the bradykinin-stimulated ERK-2 pathway is entirely cyclic AMP-sensitive, and suggests that coincident signal detection by adenylate cyclase may be an important physiological route for the modulation of early mitogenic signalling. Cyclic AMP 85-95 kininogen 1 Homo sapiens 37-47