PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 761221-5 1979 The presence of DHFR in neoplasms of central nervous system origin is relevant to the development of folate antagonists which, unlike methotrexate, can readily cross the blood-brain barrier. Folic Acid 101-107 dihydrofolate reductase Rattus norvegicus 16-20