PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7572198-1 1995 It has previously been shown that caffeine, in a dose-dependent manner, increases the expression of the protooncogene c-fos in the rat brain, predominantly in the caudate-putamen and tuberculum olfactorium. Caffeine 34-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 118-123 7572198-5 1995 Thus, c-fos is induced in rat striatum following administration of caffeine and other xanthines that (provided they enter the brain) block adenosine receptors, suggesting an involvement of central adenosine receptors. Caffeine 67-75 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 6-11