PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7565683-2	1995	Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.	Tetradecanoylphorbol Acetate	249-274	NFKB inhibitor alpha	Homo sapiens	36-51	
7565683-2	1995	Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.	Tetradecanoylphorbol Acetate	249-274	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	165-180	
7565683-2	1995	Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.	Tetradecanoylphorbol Acetate	249-274	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	220-230	
7565683-3	1995	In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein.	n-ac-leu	69-77	NFKB inhibitor alpha	Homo sapiens	227-242	
7565683-6	1995	Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein.	Serine	91-98	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	63-78	
7565683-7	1995	We propose that treatment of 70Z/3 cells with either phorbol myristate acetate or lipopolysaccharide induces a kinase activity which phosphorylates serines 32 and that these phosphorylations target the protein for rapid proteolytic degradation, possibly by the ubiquitin-26S proteasome pathway, thus allowing NF-kappa B to translocate to the nucleus and to activate gene expression.	Tetradecanoylphorbol Acetate	53-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	309-319	
7565683-7	1995	We propose that treatment of 70Z/3 cells with either phorbol myristate acetate or lipopolysaccharide induces a kinase activity which phosphorylates serines 32 and that these phosphorylations target the protein for rapid proteolytic degradation, possibly by the ubiquitin-26S proteasome pathway, thus allowing NF-kappa B to translocate to the nucleus and to activate gene expression.	Serine	148-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	309-319