PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7541794-3 1995 In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa. Tyrosine 170-178 fibronectin 1 Homo sapiens 83-94 7541794-5 1995 The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events. Genistein 31-40 interleukin 1 beta Homo sapiens 129-138 7541794-5 1995 The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events. herbimycin 45-57 interleukin 1 beta Homo sapiens 129-138 7541794-5 1995 The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events. Tyrosine 4-12 interleukin 1 beta Homo sapiens 129-138 7541794-6 1995 The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk. Tyrosine 15-23 protein tyrosine kinase 2 Homo sapiens 85-93 7541794-6 1995 The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk. Tyrosine 15-23 spleen associated tyrosine kinase Homo sapiens 141-144 7541794-7 1995 In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin. Tyrosine 55-63 spleen associated tyrosine kinase Homo sapiens 83-86 7541794-8 1995 In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected. Cytochalasin D 38-52 protein tyrosine kinase 2 Homo sapiens 92-95 7541794-8 1995 In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected. Tyrosine 64-72 protein tyrosine kinase 2 Homo sapiens 92-95