PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7519972-0 1994 Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA alkyltransferase in rat tissues. Procarbazine 24-36 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 133-169 7519972-0 1994 Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA alkyltransferase in rat tissues. Methylnitrosourea 41-58 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 133-169 7519972-7 1994 A similar depletion and slow recovery of AGT in the liver, blood lymphocytes, bone marrow and lymph nodes was observed after treatment with a single dose of 100 mg/kg procarbazine. Procarbazine 167-179 angiotensinogen Rattus norvegicus 41-44 7519972-9 1994 Similarly, a single dose of MNU (35 mg/kg) resulted in AGT depletion followed by rapid recovery in all four tissues examined. Methylnitrosourea 28-31 angiotensinogen Rattus norvegicus 55-58 7519972-10 1994 It is concluded that procarbazine (but not MNU) causes a decrease in cellular AGT concentrations by a mechanism additional to suicide repair of O6-meG. Procarbazine 21-33 angiotensinogen Rattus norvegicus 78-81