PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7500013-1	1995	Picolinic acid, a catabolite of L-tryptophan, activates the transcription of the inducible nitric oxide synthase gene (iNOS) in IFN-gamma-treated murine macrophages.	picolinic acid	0-14	nitric oxide synthase 2, inducible	Mus musculus	119-123	
7500013-1	1995	Picolinic acid, a catabolite of L-tryptophan, activates the transcription of the inducible nitric oxide synthase gene (iNOS) in IFN-gamma-treated murine macrophages.	picolinic acid	0-14	interferon gamma	Mus musculus	128-137	
7500013-1	1995	Picolinic acid, a catabolite of L-tryptophan, activates the transcription of the inducible nitric oxide synthase gene (iNOS) in IFN-gamma-treated murine macrophages.	catabolite	18-28	nitric oxide synthase 2, inducible	Mus musculus	119-123	
7500013-1	1995	Picolinic acid, a catabolite of L-tryptophan, activates the transcription of the inducible nitric oxide synthase gene (iNOS) in IFN-gamma-treated murine macrophages.	catabolite	18-28	interferon gamma	Mus musculus	128-137	
7500013-1	1995	Picolinic acid, a catabolite of L-tryptophan, activates the transcription of the inducible nitric oxide synthase gene (iNOS) in IFN-gamma-treated murine macrophages.	Tryptophan	32-44	nitric oxide synthase 2, inducible	Mus musculus	119-123	
7500013-1	1995	Picolinic acid, a catabolite of L-tryptophan, activates the transcription of the inducible nitric oxide synthase gene (iNOS) in IFN-gamma-treated murine macrophages.	Tryptophan	32-44	interferon gamma	Mus musculus	128-137	
7500013-2	1995	We performed functional studies on the 5" flanking region of the iNOS gene linked to a CAT reporter gene to identify the cis-acting element(s) responsible for the activation of iNOS transcription by picolinic acid.	picolinic acid	199-213	nitric oxide synthase 2, inducible	Mus musculus	65-69	
7500013-2	1995	We performed functional studies on the 5" flanking region of the iNOS gene linked to a CAT reporter gene to identify the cis-acting element(s) responsible for the activation of iNOS transcription by picolinic acid.	picolinic acid	199-213	nitric oxide synthase 2, inducible	Mus musculus	177-181	
7500013-3	1995	Transient transfection assays showed that the full-length iNOS promoter in the murine macrophage cell line ANA-1 was activated by the synergistic interaction between IFN-gamma and picolinic acid.	picolinic acid	180-194	nitric oxide synthase 2, inducible	Mus musculus	58-62	
7500013-4	1995	Deletion or mutation of the iNOS promoter region from -227 to -209, containing a sequence homology to a hypoxia-responsive enhancer (iNOS-HRE), decreased picolinic acid- but not LPS-induced CAT activity by more than 70%.	picolinic acid	154-168	nitric oxide synthase 2, inducible	Mus musculus	28-32	
7500013-4	1995	Deletion or mutation of the iNOS promoter region from -227 to -209, containing a sequence homology to a hypoxia-responsive enhancer (iNOS-HRE), decreased picolinic acid- but not LPS-induced CAT activity by more than 70%.	picolinic acid	154-168	nitric oxide synthase 2, inducible	Mus musculus	133-137	
7500013-5	1995	Functional studies using a tk promoter-CAT reporter gene plasmid demonstrated that the iNOS-HRE was sufficient to confer inducibility by picolinic acid but not by IFN-gamma or LPS.	picolinic acid	137-151	nitric oxide synthase 2, inducible	Mus musculus	87-91	
7500013-6	1995	Electrophoretic mobility shift assays confirmed that picolinic acid alone induced a specific binding activity to the iNOS-HRE.	picolinic acid	53-67	nitric oxide synthase 2, inducible	Mus musculus	117-121