PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7492761-3 1995 We have observed that TPO treatment of human platelets resulted in tyrosine phosphorylation of several cellular proteins, including the c-Mpl receptor and the 85-kD subunit of phosphatidylinositol 3-kinase (PI3-K). Tyrosine 67-75 thrombopoietin Homo sapiens 22-25 7492761-4 1995 TPO stimulated this tyrosine phosphorylation in a time-dependent manner, reaching a maximum in 5 minutes. Tyrosine 20-28 thrombopoietin Homo sapiens 0-3 7492761-5 1995 The tyrosine phosphorylation of PI 3-K was dependent on the concentration of TPO and reached a maximum at concentrations between 50 and 100 ng/mL. Tyrosine 4-12 thrombopoietin Homo sapiens 77-80