PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6342725-6 1983 They are also cross-resistant to hydroxyurea and guanazole, and studies on enzyme activity levels support our previous findings with cells selected for resistance to hydroxyurea, which showed changes in CDP reductase activity are not always coordinated with changes in ADP reductase. Hydroxyurea 166-177 cut like homeobox 1 Homo sapiens 203-206 6342725-8 1983 Moreover, increases in cellular resistance were accompanied by significant increases in CDP but not ADP reductase, suggesting that an ability to maintain an adequate level of CDP reductase activity is especially important to achieve resistance to DNA synthesis inhibitors like N-carbamoyloxyurea, hydroxyurea, and guanazole. carbamoyloxyurea 277-295 cut like homeobox 1 Homo sapiens 175-178 6342725-8 1983 Moreover, increases in cellular resistance were accompanied by significant increases in CDP but not ADP reductase, suggesting that an ability to maintain an adequate level of CDP reductase activity is especially important to achieve resistance to DNA synthesis inhibitors like N-carbamoyloxyurea, hydroxyurea, and guanazole. Hydroxyurea 297-308 cut like homeobox 1 Homo sapiens 88-91 6342725-8 1983 Moreover, increases in cellular resistance were accompanied by significant increases in CDP but not ADP reductase, suggesting that an ability to maintain an adequate level of CDP reductase activity is especially important to achieve resistance to DNA synthesis inhibitors like N-carbamoyloxyurea, hydroxyurea, and guanazole. Hydroxyurea 297-308 cut like homeobox 1 Homo sapiens 175-178 6342725-8 1983 Moreover, increases in cellular resistance were accompanied by significant increases in CDP but not ADP reductase, suggesting that an ability to maintain an adequate level of CDP reductase activity is especially important to achieve resistance to DNA synthesis inhibitors like N-carbamoyloxyurea, hydroxyurea, and guanazole. Guanazole 314-323 cut like homeobox 1 Homo sapiens 88-91 6342725-8 1983 Moreover, increases in cellular resistance were accompanied by significant increases in CDP but not ADP reductase, suggesting that an ability to maintain an adequate level of CDP reductase activity is especially important to achieve resistance to DNA synthesis inhibitors like N-carbamoyloxyurea, hydroxyurea, and guanazole. Guanazole 314-323 cut like homeobox 1 Homo sapiens 175-178