PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35599279-8 2022 RESULTS: In ARPE-19 cells exposed to high-glucose conditions, the mRNA and secretory protein levels of VEGF, p-JAK1, p-JAK2, p-STAT3, and p-STAT5 levels were significantly increased. Glucose 42-49 vascular endothelial growth factor A Homo sapiens 103-107 35599279-8 2022 RESULTS: In ARPE-19 cells exposed to high-glucose conditions, the mRNA and secretory protein levels of VEGF, p-JAK1, p-JAK2, p-STAT3, and p-STAT5 levels were significantly increased. Glucose 42-49 Janus kinase 1 Homo sapiens 111-115 35599279-8 2022 RESULTS: In ARPE-19 cells exposed to high-glucose conditions, the mRNA and secretory protein levels of VEGF, p-JAK1, p-JAK2, p-STAT3, and p-STAT5 levels were significantly increased. Glucose 42-49 Janus kinase 2 Homo sapiens 119-123 35599279-8 2022 RESULTS: In ARPE-19 cells exposed to high-glucose conditions, the mRNA and secretory protein levels of VEGF, p-JAK1, p-JAK2, p-STAT3, and p-STAT5 levels were significantly increased. Glucose 42-49 signal transducer and activator of transcription 3 Homo sapiens 127-132 35599279-8 2022 RESULTS: In ARPE-19 cells exposed to high-glucose conditions, the mRNA and secretory protein levels of VEGF, p-JAK1, p-JAK2, p-STAT3, and p-STAT5 levels were significantly increased. Glucose 42-49 signal transducer and activator of transcription 5A Homo sapiens 140-145 35599279-9 2022 Treatment with JAKiI, tofacitinib, and STAT3i significantly suppressed VEGF to basal levels at both the mRNA and secretory levels in vitro. tofacitinib 22-33 vascular endothelial growth factor A Homo sapiens 71-75 35599279-10 2022 In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction. Streptozocin 3-6 Janus kinase 1 Mus musculus 49-53 35599279-10 2022 In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction. Streptozocin 3-6 Janus kinase 2 Mus musculus 57-61 35599279-10 2022 In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction. Streptozocin 3-6 Janus kinase 3 Mus musculus 65-69 35599279-10 2022 In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction. Streptozocin 3-6 signal transducer and activator of transcription 3 Mus musculus 73-78 35599279-10 2022 In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction. Streptozocin 3-6 vascular endothelial growth factor A Mus musculus 84-88 35599279-12 2022 Increased p-JAK1 and VEGF in STZ-induced mice were significantly reduced by JAKiI (p < 0.05, p < 0.001) and tofacitinib (p < 0.001, respectively). Streptozocin 29-32 Janus kinase 1 Mus musculus 12-16 35599279-12 2022 Increased p-JAK1 and VEGF in STZ-induced mice were significantly reduced by JAKiI (p < 0.05, p < 0.001) and tofacitinib (p < 0.001, respectively). Streptozocin 29-32 vascular endothelial growth factor A Mus musculus 21-25 35599279-12 2022 Increased p-JAK1 and VEGF in STZ-induced mice were significantly reduced by JAKiI (p < 0.05, p < 0.001) and tofacitinib (p < 0.001, respectively). tofacitinib 108-119 Janus kinase 1 Mus musculus 12-16 35599279-12 2022 Increased p-JAK1 and VEGF in STZ-induced mice were significantly reduced by JAKiI (p < 0.05, p < 0.001) and tofacitinib (p < 0.001, respectively). tofacitinib 108-119 vascular endothelial growth factor A Mus musculus 21-25