PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35512065-5 2022 METHODS: In this study, for the first time, compound 5 possessing a novel salicylamide zinc-binding group was synthesized and evaluated biologically for its ability to inhibit various HDAC isoforms and induce acetylation upon alpha-tubulin and histone H3 among MDA-MB-231 cells. salicylamide 74-86 tubulin alpha 1b Homo sapiens 226-239 35512065-8 2022 Moreover, the molecular docking study indicated that the salicylamide zinc-binding group of compound 5 coordinates the active zinc ion of class I HDAC2 in a bidentate fashion. salicylamide 57-69 histone deacetylase 2 Homo sapiens 146-151