PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35473510-7 2022 CONCLUSION: Upfront testing of DPYD variants appears to reduce the toxicity burden of Capecitabine and 5-FU in cancer patients and can lead to substantial hospital cost savings, only if the dose management of the drugs in response to variants detected is standardised and regulated. Fluorouracil 103-107 dihydropyrimidine dehydrogenase Homo sapiens 31-35