PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35396645-1 2022 PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels. Glucose 126-133 sirtuin 1 Mus musculus 13-50 35396645-1 2022 PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels. Glucose 126-133 sirtuin 1 Mus musculus 52-57 35396645-1 2022 PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels. Phosphates 146-155 sirtuin 1 Mus musculus 13-50 35396645-1 2022 PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels. Phosphates 146-155 sirtuin 1 Mus musculus 52-57 35396645-7 2022 RESULTS: Mouse VSMCs exposed to high phosphate and high glucose in vitro showed increased calcification, which was correlated with the induction of cell senescence, as confirmed by the increased SA-beta-galactosidase activity and p21 expression. Phosphates 37-46 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 230-233 35396645-7 2022 RESULTS: Mouse VSMCs exposed to high phosphate and high glucose in vitro showed increased calcification, which was correlated with the induction of cell senescence, as confirmed by the increased SA-beta-galactosidase activity and p21 expression. Glucose 56-63 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 230-233 35396645-9 2022 In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification. sirtinol 13-21 sirtuin 1 Mus musculus 39-44 35396645-9 2022 In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification. sirtinol 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 35396645-9 2022 In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification. sirtinol 13-21 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 87-96 35396645-10 2022 CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression. Glucose 18-25 sirtuin 1 Mus musculus 173-178 35396645-10 2022 CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression. Phosphates 35-44 sirtuin 1 Mus musculus 173-178 35396645-10 2022 CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression. Glucose 139-146 sirtuin 1 Mus musculus 173-178 35396645-10 2022 CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression. Phosphates 151-160 sirtuin 1 Mus musculus 173-178