PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35396645-1	2022	PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels.	Glucose	126-133	sirtuin 1	Mus musculus	13-50	
35396645-1	2022	PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels.	Glucose	126-133	sirtuin 1	Mus musculus	52-57	
35396645-1	2022	PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels.	Phosphates	146-155	sirtuin 1	Mus musculus	13-50	
35396645-1	2022	PURPOSE: The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), plays an important role in vascular calcification induced by high glucose and/or high phosphate levels.	Phosphates	146-155	sirtuin 1	Mus musculus	52-57	
35396645-7	2022	RESULTS: Mouse VSMCs exposed to high phosphate and high glucose in vitro showed increased calcification, which was correlated with the induction of cell senescence, as confirmed by the increased SA-beta-galactosidase activity and p21 expression.	Phosphates	37-46	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	230-233	
35396645-7	2022	RESULTS: Mouse VSMCs exposed to high phosphate and high glucose in vitro showed increased calcification, which was correlated with the induction of cell senescence, as confirmed by the increased SA-beta-galactosidase activity and p21 expression.	Glucose	56-63	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	230-233	
35396645-9	2022	In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification.	sirtinol	13-21	sirtuin 1	Mus musculus	39-44	
35396645-9	2022	In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification.	sirtinol	13-21	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	56-59	
35396645-9	2022	In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification.	sirtinol	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96	
35396645-10	2022	CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression.	Glucose	18-25	sirtuin 1	Mus musculus	173-178	
35396645-10	2022	CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression.	Phosphates	35-44	sirtuin 1	Mus musculus	173-178	
35396645-10	2022	CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression.	Glucose	139-146	sirtuin 1	Mus musculus	173-178	
35396645-10	2022	CONCLUSIONS: High glucose and high phosphate levels induce senescence and vascular calcification in VSMCs, and the combined effect of high glucose and phosphate can inhibit SIRT1 expression.	Phosphates	151-160	sirtuin 1	Mus musculus	173-178