PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35395919-2	2022	In the present study, we established a population pharmacokinetic model to explore the effect of combined use of Wuzhi capsules/echinocandins and the patients" biochemical parameters such as hematocrit on blood concentrations and target doses of tacrolimus in renal transplant patients with different CYP3A5 genotypes.	Tacrolimus	246-256	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	301-307	
35395919-7	2022	CYP3A5 genotypes and co-administration of Wuzhi capsules, as well as time after renal transplantation and hematocrit, were important factors affecting the clearance of tacrolimus.	Tacrolimus	168-178	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	0-6	
35395919-9	2022	The Monte Carlo simulation indicated the following recommended doses of tacrolimus alone: 0.14 mg kg-1 d-1 for genotype CYP3A5*1*1, 0.12 mg kg-1 d-1 for CYP3A5*1*3, and 0.10 mg kg-1 d-1 for CYP3A5*3*3.	Tacrolimus	72-82	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	120-126	
35395919-9	2022	The Monte Carlo simulation indicated the following recommended doses of tacrolimus alone: 0.14 mg kg-1 d-1 for genotype CYP3A5*1*1, 0.12 mg kg-1 d-1 for CYP3A5*1*3, and 0.10 mg kg-1 d-1 for CYP3A5*3*3.	Tacrolimus	72-82	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	153-159	
35395919-9	2022	The Monte Carlo simulation indicated the following recommended doses of tacrolimus alone: 0.14 mg kg-1 d-1 for genotype CYP3A5*1*1, 0.12 mg kg-1 d-1 for CYP3A5*1*3, and 0.10 mg kg-1 d-1 for CYP3A5*3*3.	Tacrolimus	72-82	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	190-196	
35395919-10	2022	For patients receiving the combination with Wuzhi capsules, the recommended doses of tacrolimus were 0.10 mg kg-1 d-1 for CYP3A5*1*1, 0.08 mg kg-1 d-1 for CYP3A5*1*3, and 0.06 mg kg-1 d-1 for CYP3A5*3*3 genotypes.	Tacrolimus	85-95	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	122-128	
35395919-10	2022	For patients receiving the combination with Wuzhi capsules, the recommended doses of tacrolimus were 0.10 mg kg-1 d-1 for CYP3A5*1*1, 0.08 mg kg-1 d-1 for CYP3A5*1*3, and 0.06 mg kg-1 d-1 for CYP3A5*3*3 genotypes.	Tacrolimus	85-95	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	155-161	
35395919-10	2022	For patients receiving the combination with Wuzhi capsules, the recommended doses of tacrolimus were 0.10 mg kg-1 d-1 for CYP3A5*1*1, 0.08 mg kg-1 d-1 for CYP3A5*1*3, and 0.06 mg kg-1 d-1 for CYP3A5*3*3 genotypes.	Tacrolimus	85-95	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	192-198	
35395919-12	2022	For early kidney transplant recipients receiving tacrolimus treatment, not only body weight, but also CYP3A5 genotypes and drugs used in combination should be considered when determining the target dose of tacrolimus.	Tacrolimus	206-216	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	102-108