PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35366176-0	2022	Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-kappaB and upregulating PPAR-gamma signal.	diacerein	0-9	toll-like receptor 4	Rattus norvegicus	80-84	
35366176-5	2022	Hence, this study attempted to evaluate the impact of DIA treatment on liver injury induced by APAP and its influence on nuclear factor-kappaB (NF-kappaB) /toll-like receptor 4 (TLR4)/high mobility group box-1(HMGB-1) signaling as well as the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression.	diacerein	54-57	toll-like receptor 4	Rattus norvegicus	156-176	
35366176-5	2022	Hence, this study attempted to evaluate the impact of DIA treatment on liver injury induced by APAP and its influence on nuclear factor-kappaB (NF-kappaB) /toll-like receptor 4 (TLR4)/high mobility group box-1(HMGB-1) signaling as well as the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression.	diacerein	54-57	toll-like receptor 4	Rattus norvegicus	178-182	
35366176-13	2022	CONCLUSIONS: This study demonstrated that DIA exerts anti-apoptotic, anti-inflammatory, and antioxidant properties against liver injury induced by APAP that is attributed to inhibition of the HMGB1/TLR4/NF-kappaB pathway, besides upregulation of the expression of PPAR-gamma.	diacerein	42-45	toll-like receptor 4	Rattus norvegicus	198-202