PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35340409-0 2022 ETC-1002 Attenuates Porphyromonas gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-kappaB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid 0-8 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-125 35340409-9 2022 Results: ETC-1002 inhibited the production of proinflammatory cytokines, promoted AMPK phosphorylation, and decreased IkappaBalpha and NF-kappaB p65 phosphorylation levels in Pg-LPS-treated RAW264.7 macrophages. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid 9-17 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 118-130 35340409-9 2022 Results: ETC-1002 inhibited the production of proinflammatory cytokines, promoted AMPK phosphorylation, and decreased IkappaBalpha and NF-kappaB p65 phosphorylation levels in Pg-LPS-treated RAW264.7 macrophages. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid 9-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 135-144 35340409-9 2022 Results: ETC-1002 inhibited the production of proinflammatory cytokines, promoted AMPK phosphorylation, and decreased IkappaBalpha and NF-kappaB p65 phosphorylation levels in Pg-LPS-treated RAW264.7 macrophages. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid 9-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 35340409-9 2022 Results: ETC-1002 inhibited the production of proinflammatory cytokines, promoted AMPK phosphorylation, and decreased IkappaBalpha and NF-kappaB p65 phosphorylation levels in Pg-LPS-treated RAW264.7 macrophages. pg-lps 175-181 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 118-130 35340409-13 2022 Conclusions: ETC-1002 exerts anti-inflammatory effects in Pg-LPS-treated RAW264.7 cells via the AMPK/NF-kappaB pathway in vitro and inhibits the progress of experimental periodontitis in mice in an AMPK signaling-dependent manner in vivo. pg-lps 58-64 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 101-110