PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35306927-6 2022 While classical estrogens (such as estradiol) exert their actions via both activation of nuclear and membrane estrogen receptor alpha (ERalpha), E4 presents a specific profile of ERalpha activation: E4 binds and activates nuclear ERalpha but does not induce the activation of membrane ERalpha signaling pathways in specific tissues. Estradiol 35-44 estrogen receptor 1 Homo sapiens 135-142 35306927-6 2022 While classical estrogens (such as estradiol) exert their actions via both activation of nuclear and membrane estrogen receptor alpha (ERalpha), E4 presents a specific profile of ERalpha activation: E4 binds and activates nuclear ERalpha but does not induce the activation of membrane ERalpha signaling pathways in specific tissues. Estradiol 35-44 estrogen receptor 1 Homo sapiens 179-186 35306927-6 2022 While classical estrogens (such as estradiol) exert their actions via both activation of nuclear and membrane estrogen receptor alpha (ERalpha), E4 presents a specific profile of ERalpha activation: E4 binds and activates nuclear ERalpha but does not induce the activation of membrane ERalpha signaling pathways in specific tissues. Estradiol 35-44 estrogen receptor 1 Homo sapiens 230-237