PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35306537-4 2022 Levels of phosphorylated IkBalpha and p65 significantly rose in mdx/mTR-/- dystrophic hearts and Wt1 expression declined in the epicardium of mdx/mTR-/- mice when nuclear factor kappaB (NF-kappaB) and inflammation were inhibited by metformin. Metformin 232-241 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 25-33 35306537-4 2022 Levels of phosphorylated IkBalpha and p65 significantly rose in mdx/mTR-/- dystrophic hearts and Wt1 expression declined in the epicardium of mdx/mTR-/- mice when nuclear factor kappaB (NF-kappaB) and inflammation were inhibited by metformin. Metformin 232-241 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 35306537-4 2022 Levels of phosphorylated IkBalpha and p65 significantly rose in mdx/mTR-/- dystrophic hearts and Wt1 expression declined in the epicardium of mdx/mTR-/- mice when nuclear factor kappaB (NF-kappaB) and inflammation were inhibited by metformin. Metformin 232-241 WT1 transcription factor Mus musculus 97-100 35306537-7 2022 Our study demonstrates that upregulation of Wt1 in epicardial cells contributes to fibrosis in dystrophic hearts and metformin-mediated inhibition of NF-kappaB can ameliorate the pathology, and thus showing clinical potential for dystrophic cardiomyopathy. Metformin 117-126 WT1 transcription factor Mus musculus 44-47 35306537-7 2022 Our study demonstrates that upregulation of Wt1 in epicardial cells contributes to fibrosis in dystrophic hearts and metformin-mediated inhibition of NF-kappaB can ameliorate the pathology, and thus showing clinical potential for dystrophic cardiomyopathy. Metformin 117-126 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 150-159