PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35298792-5	2022	Our results show that morphine reduced the expression of G protein-coupled receptor 173 (GPR173) in M17 neuronal cells.	Morphine	22-30	G protein-coupled receptor 173	Homo sapiens	57-87	
35298792-5	2022	Our results show that morphine reduced the expression of G protein-coupled receptor 173 (GPR173) in M17 neuronal cells.	Morphine	22-30	G protein-coupled receptor 173	Homo sapiens	89-95	
35298792-6	2022	Therefore, we speculated that phoenixin-14, as a ligand for GPR173, may be involved in the morphine-mediated response in M17 cells.	phoenixin-14	30-42	G protein-coupled receptor 173	Homo sapiens	60-66	
35298792-7	2022	Further, we found that phoenixin-14 mitigated morphine-induced oxidative stress by reducing the reactive oxygen species (ROS) production and increasing superoxide dismutase (SOD) activity in M17 neuronal cells.	phoenixin-14	23-35	superoxide dismutase 1	Homo sapiens	152-172	
35298792-7	2022	Further, we found that phoenixin-14 mitigated morphine-induced oxidative stress by reducing the reactive oxygen species (ROS) production and increasing superoxide dismutase (SOD) activity in M17 neuronal cells.	phoenixin-14	23-35	superoxide dismutase 1	Homo sapiens	174-177	
35298792-7	2022	Further, we found that phoenixin-14 mitigated morphine-induced oxidative stress by reducing the reactive oxygen species (ROS) production and increasing superoxide dismutase (SOD) activity in M17 neuronal cells.	Morphine	46-54	superoxide dismutase 1	Homo sapiens	152-172	
35298792-7	2022	Further, we found that phoenixin-14 mitigated morphine-induced oxidative stress by reducing the reactive oxygen species (ROS) production and increasing superoxide dismutase (SOD) activity in M17 neuronal cells.	Morphine	46-54	superoxide dismutase 1	Homo sapiens	174-177	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	phoenixin-14	0-12	H3 histone pseudogene 16	Homo sapiens	113-116	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	phoenixin-14	0-12	cyclin dependent kinase 6	Homo sapiens	118-144	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	phoenixin-14	0-12	cyclin dependent kinase 6	Homo sapiens	146-150	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	phoenixin-14	0-12	RB transcriptional corepressor 1	Homo sapiens	157-161	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	Morphine	26-34	H3 histone pseudogene 16	Homo sapiens	113-116	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	Morphine	26-34	cyclin dependent kinase 6	Homo sapiens	118-144	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	Morphine	26-34	cyclin dependent kinase 6	Homo sapiens	146-150	
35298792-9	2022	Phoenixin-14 resolved the morphine-caused cell cycle arrest with significant changes in the expression levels of p21, cyclin-dependent kinases 6 (CDK6), and p-Rb.	Morphine	26-34	RB transcriptional corepressor 1	Homo sapiens	157-161	
35298792-10	2022	It also elevated the telomerase activity and restored the expressions of human telomerase reverse transcriptase (hTERT) and TERF2 in morphine-induced M17 neuronal cells.	Morphine	133-141	telomerase reverse transcriptase	Homo sapiens	113-118	
35298792-10	2022	It also elevated the telomerase activity and restored the expressions of human telomerase reverse transcriptase (hTERT) and TERF2 in morphine-induced M17 neuronal cells.	Morphine	133-141	telomeric repeat binding factor 2	Homo sapiens	124-129	
35298792-11	2022	Furthermore, phoenixin-14 restored the yes-associated protein (YAP) expression against morphine in M17 neuronal cells.	phoenixin-14	13-25	Yes1 associated transcriptional regulator	Homo sapiens	39-61	
35298792-11	2022	Furthermore, phoenixin-14 restored the yes-associated protein (YAP) expression against morphine in M17 neuronal cells.	phoenixin-14	13-25	Yes1 associated transcriptional regulator	Homo sapiens	63-66	
35298792-11	2022	Furthermore, phoenixin-14 restored the yes-associated protein (YAP) expression against morphine in M17 neuronal cells.	Morphine	87-95	Yes1 associated transcriptional regulator	Homo sapiens	39-61	
35298792-11	2022	Furthermore, phoenixin-14 restored the yes-associated protein (YAP) expression against morphine in M17 neuronal cells.	Morphine	87-95	Yes1 associated transcriptional regulator	Homo sapiens	63-66	
35298792-12	2022	Knockdown of YAP abolished the beneficial effects of phoenixin-14 on cellular senescence against morphine induction.	phoenixin-14	53-65	Yes1 associated transcriptional regulator	Homo sapiens	13-16	
35298792-12	2022	Knockdown of YAP abolished the beneficial effects of phoenixin-14 on cellular senescence against morphine induction.	Morphine	97-105	Yes1 associated transcriptional regulator	Homo sapiens	13-16	
35298792-13	2022	Taken together, these aggregate data demonstrate that phoenixin-14 prevented cellular senescence against morphine induction in M17 neuronal cells via regulating YAP expression.	phoenixin-14	54-66	Yes1 associated transcriptional regulator	Homo sapiens	161-164