PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35291604-1	2022	Background: This study evaluates the effect of simultaneous AKT inhibition and cisplatin therapy in changes of Reactive Oxygen Species (ROS) production, apoptosis induction, and cell survival in cisplatin-resistant OVCAR3 cell.	Cisplatin	195-204	AKT serine/threonine kinase 1	Homo sapiens	60-63	
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Cisplatin	69-78	AKT serine/threonine kinase 1	Homo sapiens	288-291	
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Cisplatin	69-78	AKT serine/threonine kinase 1	Homo sapiens	347-350	
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Cisplatin	117-126	AKT serine/threonine kinase 1	Homo sapiens	288-291	
35291604-5	2022	Results: The results showed that all three treated groups, including cisplatin and Ly alone and co-administration of cisplatin+Ly, could reduce the cell vitality of OVCAR3 cancer cells, induced intracellular production of ROS and increased the expression level of activated caspase 3 and Akt protein, whereas down-regulated the phosphorylation of Akt protein.	Cisplatin	117-126	AKT serine/threonine kinase 1	Homo sapiens	347-350	
35291604-8	2022	Conclusion: The results showed that the AKT inhibition by Ly could sensitize the OVCAR3 cancer cells to the cisplatin and lower the effective dose of cisplatin through hyperactivation of oxidative stress.	Cisplatin	108-117	AKT serine/threonine kinase 1	Homo sapiens	40-43	
35291604-8	2022	Conclusion: The results showed that the AKT inhibition by Ly could sensitize the OVCAR3 cancer cells to the cisplatin and lower the effective dose of cisplatin through hyperactivation of oxidative stress.	Cisplatin	150-159	AKT serine/threonine kinase 1	Homo sapiens	40-43