PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35154461-0 2022 Targeted inhibition of ACLY expression to reverse the resistance of sorafenib in hepatocellular carcinoma. Sorafenib 68-77 ATP citrate lyase Homo sapiens 23-27 35154461-11 2022 ACLY expression was higher in sorafenib-resistant cells and HCC-cell sensitivity to sorafenib increased after ACLY-knockout. Sorafenib 30-39 ATP citrate lyase Homo sapiens 0-4 35154461-11 2022 ACLY expression was higher in sorafenib-resistant cells and HCC-cell sensitivity to sorafenib increased after ACLY-knockout. Sorafenib 84-93 ATP citrate lyase Homo sapiens 110-114 35154461-14 2022 These data suggest that ACLY downregulation can reverse sorafenib resistance, and that SS-PEI can be used to mediate shRNA-ACLY transfection in HCC treatment. Sorafenib 56-65 ATP citrate lyase Homo sapiens 24-28