PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35119252-6	2022	Different drugs inhibiting PDE5 (PDE5i) exist, the main of which commercially available are sildenafil, vardenafil, tadalafil, and avanafil.	Tadalafil	116-125	phosphodiesterase 5A	Homo sapiens	27-31	
35119252-6	2022	Different drugs inhibiting PDE5 (PDE5i) exist, the main of which commercially available are sildenafil, vardenafil, tadalafil, and avanafil.	Tadalafil	116-125	phosphodiesterase 5A	Homo sapiens	33-38	
35119252-7	2022	The PDE5i tadalafil may influence cellular physiology and endocrine-metabolic pathways in skeletal muscles and exerts its functions both by activating the cell signaling linked to the insulin-related metabolic pathways and modulating the endocrine responses, protein catabolism and hormone-related anabolism/catabolism during and after physical exercise-related stress.	Tadalafil	10-19	phosphodiesterase 5A	Homo sapiens	4-9	
35119252-8	2022	Based on recent in vivo and in vitro findings, in this narrative review we summarized the available evidence describing the interactions between the PDE5i tadalafil and steroid hormones in skeletal muscle tissue and physical exercise adaptation, focusing our interest on their possible synergistic or competitive action(s) on muscle metabolism and function.	Tadalafil	155-164	phosphodiesterase 5A	Homo sapiens	149-154