PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3490850-0	1986	Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	44-57	
3490850-1	1986	When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts.	Hyaluronic Acid	86-101	interleukin 1 alpha	Homo sapiens	135-148	
3490850-1	1986	When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts.	Hyaluronic Acid	86-101	interleukin 1 alpha	Homo sapiens	150-154	
3490850-2	1986	A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing activity.	Hyaluronic Acid	15-30	interleukin 1 alpha	Homo sapiens	73-77	
3490850-4	1986	Hyaluronic acid also stimulated human polymorphonuclear leucocytes to produce IL-1 like activity.	Hyaluronic Acid	0-15	interleukin 1 alpha	Homo sapiens	78-82	
3490850-5	1986	These results indicate that hyaluronic acid is an endogenous IL-1 inducer and may play important roles in the pathological and/or physiological changes of connective tissues.	Hyaluronic Acid	28-43	interleukin 1 alpha	Homo sapiens	61-65