PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34878954-0 2021 Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. ros 93-96 tumor protein p53 Homo sapiens 104-108 34878954-0 2021 Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. ros 93-96 tumor protein p53 Homo sapiens 109-112 34878954-2 2021 This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. ros 119-122 tumor protein p53 Homo sapiens 132-136 34878954-2 2021 This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. ros 119-122 tumor protein p53 Homo sapiens 137-140 34878954-5 2021 Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP53 activity, which in turn modulates expression of its downstream targets which are involved in a broad spectrum of the metastatic cascade to suppress metastasis including MMP members and TWIST. ros 40-43 tumor protein p53 Homo sapiens 102-106 34878954-6 2021 In summary, our findings have established a mechanism by which autophagy inhibition suppresses metastasis via the ROS-TP53 signaling pathway. ros 114-117 tumor protein p53 Homo sapiens 118-122