PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34843983-0 2022 Vesicular IFN-gamma as a cooperative attacker to enhance anti-cancer effect of 5-fluorouracil via thymidine phosphorylase upregulation and tumor microenvironment normalization. Fluorouracil 79-93 thymidine phosphorylase Homo sapiens 98-121 34843983-1 2022 On the basis of immuno-modulating effect and upregulating the activity of thymidine phosphorylase (TP), interferon-gamma (IFN-gamma) as a cooperative attacker was explored to enhance the anticancer activity of 5-FU. Fluorouracil 210-214 thymidine phosphorylase Homo sapiens 74-97 34843983-1 2022 On the basis of immuno-modulating effect and upregulating the activity of thymidine phosphorylase (TP), interferon-gamma (IFN-gamma) as a cooperative attacker was explored to enhance the anticancer activity of 5-FU. Fluorouracil 210-214 thymidine phosphorylase Homo sapiens 99-101 34843983-3 2022 The IFN-gamma-EDP vesicles allowed IFN-gamma to accumulate at the tumor site and be taken up by tumor cells, resulting in significantly upregulated expression level of TP, distinct inhibition of cell growth, more cellular apoptosis and more serious cell cycle arrest when administrated combined with 5-FU. Fluorouracil 300-304 thymidine phosphorylase Homo sapiens 168-170