PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34827649-0	2021	Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?	Tretinoin	53-66	desmoglein 1	Homo sapiens	16-20	
34827649-0	2021	Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?	Tretinoin	53-66	keratin 3	Homo sapiens	25-29	
34827649-0	2021	Similarities in DSG1 and KRT3 Downregulation through Retinoic Acid Treatment and PAX6 Knockdown Related Expression Profiles: Does PAX6 Affect RA Signaling in Limbal Epithelial Cells?	Radium	142-144	paired box 6	Homo sapiens	130-134	
34827649-2	2021	In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1, Aldehyde dehydrogenase family 1 member A3) have been described in limbal epithelial cells (LECs) and conjunctival epithelial cells.	Vitamin A	44-51	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Homo sapiens	73-77	
34827649-2	2021	In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1, Aldehyde dehydrogenase family 1 member A3) have been described in limbal epithelial cells (LECs) and conjunctival epithelial cells.	Vitamin A	44-51	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Homo sapiens	79-112	
34827649-2	2021	In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1, Aldehyde dehydrogenase family 1 member A3) have been described in limbal epithelial cells (LECs) and conjunctival epithelial cells.	Vitamin A	44-51	aldehyde dehydrogenase 1 family member A1	Homo sapiens	118-128	
34827649-2	2021	In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1, Aldehyde dehydrogenase family 1 member A3) have been described in limbal epithelial cells (LECs) and conjunctival epithelial cells.	Vitamin A	44-51	aldehyde dehydrogenase 1 family member A1	Homo sapiens	130-153	
34827649-2	2021	In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 (All-trans-retinol dehydrogenase 7) and ALDH1A1/A3 (Retinal dehydrogenase 1, Aldehyde dehydrogenase family 1 member A3) have been described in limbal epithelial cells (LECs) and conjunctival epithelial cells.	Vitamin A	44-51	aldehyde dehydrogenase 1 family member A3	Homo sapiens	155-196	
34827649-3	2021	The aim of this study was to identify the role of retinol derivates in the differentiation of human LEC and its potential impact on aniridia-associated keratopathy development.	Vitamin A	50-57	C-C motif chemokine ligand 16	Homo sapiens	100-103	
34827649-6	2021	DSG1 (Desmoglein 1), KRT3 (Keratin 3), and SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) mRNA expression was downregulated when retinoid derivates were used.	Retinoids	131-139	desmoglein 1	Homo sapiens	0-4	
34827649-6	2021	DSG1 (Desmoglein 1), KRT3 (Keratin 3), and SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) mRNA expression was downregulated when retinoid derivates were used.	Retinoids	131-139	desmoglein 1	Homo sapiens	6-18	
34827649-6	2021	DSG1 (Desmoglein 1), KRT3 (Keratin 3), and SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) mRNA expression was downregulated when retinoid derivates were used.	Retinoids	131-139	keratin 3	Homo sapiens	21-25	
34827649-6	2021	DSG1 (Desmoglein 1), KRT3 (Keratin 3), and SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) mRNA expression was downregulated when retinoid derivates were used.	Retinoids	131-139	keratin 3	Homo sapiens	27-36	
34827649-6	2021	DSG1 (Desmoglein 1), KRT3 (Keratin 3), and SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) mRNA expression was downregulated when retinoid derivates were used.	Retinoids	131-139	serine peptidase inhibitor Kazal type 7	Homo sapiens	43-49	
34827649-6	2021	DSG1 (Desmoglein 1), KRT3 (Keratin 3), and SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) mRNA expression was downregulated when retinoid derivates were used.	Retinoids	131-139	serine peptidase inhibitor Kazal type 7	Homo sapiens	51-90	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	Homo sapiens	48-52	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	keratin 3	Homo sapiens	54-58	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	desmoglein 1	Homo sapiens	64-68	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	keratin 12	Homo sapiens	114-119	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	keratin 12	Homo sapiens	121-131	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	keratin 19	Homo sapiens	137-142	
34827649-7	2021	AGN 193109 treatment led to the upregulation of ADH7, KRT3, and DSG1 mRNA expression and to the downregulation of KRT12 (Keratin 12) and KRT19 (Keratin 19) mRNA expression.	AGN 193109	0-10	keratin 19	Homo sapiens	144-154	
34827649-9	2021	An elevated concentration of retinol derivatives in LEC or an altered response to retinoids may contribute to this pattern.	Vitamin A	29-36	C-C motif chemokine ligand 16	Homo sapiens	52-55