PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34794098-7 2021 The most balanced potent and safe derivatives; 5i and 5q were more active than 5-fluorouracil, exhibited low mumrange MDM2 binding (KD=1.32and 1.72 mum, respectively), induced apoptosis-dependent anticancer activities up to 50%, activated p53 by 47-63%, downregulated the BCL2 gene to 59.8%, and reduced its protein level (13.75%) in the treated cancer cells. Fluorouracil 79-93 BCL2 apoptosis regulator Homo sapiens 272-276