PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34687898-0	2022	Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice.	Berberine	23-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	136-140	
34687898-1	2022	OBJECTIVE: We investigated the effect of berberine, a natural plant product that can activate AMP-activated protein kinase (AMPK), on OA development and associated pain in mice.	Berberine	41-50	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	124-128	
34687898-2	2022	DESIGN: Human primary knee chondrocytes were utilized to investigate how AMPK is activated by berberine.	Berberine	94-103	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	73-77	
34687898-8	2022	RESULTS: Berberine induced phosphorylation of AMPKalpha (Thr172) via liver kinase B1 (LKB1), the major upstream kinase of AMPK, in chondrocytes in vitro.	Berberine	9-18	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	122-126	
34687898-11	2022	IHC analysis of WT DMM knee cartilage further revealed that berberine inhibited concomitant loss of expression and phosphorylation of AMPKalpha and expression of SIRT1 and SIRT3, suggesting an important role of activation of AMPK signaling in mediating beneficial effect of berberine.	Berberine	60-69	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	225-229	
34687898-11	2022	IHC analysis of WT DMM knee cartilage further revealed that berberine inhibited concomitant loss of expression and phosphorylation of AMPKalpha and expression of SIRT1 and SIRT3, suggesting an important role of activation of AMPK signaling in mediating beneficial effect of berberine.	Berberine	274-283	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	225-229	
34687898-12	2022	CONCLUSIONS: Berberine acts through AMPK to reduce joint structural damage and pain associated with post-traumatic OA in mice in vivo.	Berberine	13-22	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-40