PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34662393-1 2022 Covalent Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib have proven to be highly beneficial in the treatment of chronic lymphocytic leukemia (CLL). ibrutinib 57-66 Bruton agammaglobulinemia tyrosine kinase Mus musculus 9-31 34662393-1 2022 Covalent Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib have proven to be highly beneficial in the treatment of chronic lymphocytic leukemia (CLL). ibrutinib 57-66 Bruton agammaglobulinemia tyrosine kinase Mus musculus 33-36 34662393-11 2022 Thus, non-covalent BTK/ITK inhibitors such as vecabrutinib may be efficacious in C481S BTK mutant CLL, while preserving the T-cell immunomodulatory function of ibrutinib. ibrutinib 160-169 Bruton agammaglobulinemia tyrosine kinase Mus musculus 19-22