PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3463439-3 1986 We propose that in these patients the 11 beta-HSD deficiency impairs the metabolism of cortisol to cortisone, resulting in a prolonged cortisol half-life, suppression of ACTH, and normal serum cortisol. Cortisone 99-108 proopiomelanocortin Homo sapiens 170-174